Glutathione Information and References

1:	Shamsi FA, Chaudhry IA, Boulton ME, Al-Rajhi AA.
	L-carnitine protects human retinal pigment epithelial cells from oxidative damage. Curr Eye Res. 2007 Jun;32(6):575-84. PMID: 17612973 [PubMed - indexed for MEDLINE]

2:	Bridges CC, Battle JR, Zalups RK.
	Transport of thiol-conjugates of inorganic mercury in human retinal pigment epithelial cells. Toxicol Appl Pharmacol. 2007 Jun 1;221(2):251-60. Epub 2007 Mar 23. PMID: 17467761 [PubMed - indexed for MEDLINE]

3:	Milbury PE, Graf B, Curran-Celentano JM, Blumberg JB.
	Bilberry (Vaccinium myrtillus) anthocyanins modulate heme oxygenase-1 and glutathione S-transferase-pi expression in ARPE-19 cells. Invest Ophthalmol Vis Sci. 2007 May;48(5):2343-9. PMID: 17460300 [PubMed - indexed for MEDLINE]

4:	Jia L, Liu Z, Sun L, Miller SS, Ames BN, Cotman CW, Liu J.
	Acrolein, a toxicant in cigarette smoke, causes oxidative damage and mitochondrial dysfunction in RPE cells: protection by (R)-alpha-lipoic acid. Invest Ophthalmol Vis Sci. 2007 Jan;48(1):339-48. PMID: 17197552 [PubMed - indexed for MEDLINE]

5:	Qin S, McLaughlin AP, De Vries GW.
	Protection of RPE cells from oxidative injury by 15-deoxy-delta12,14-prostaglandin J2 by augmenting GSH and activating MAPK. Invest Ophthalmol Vis Sci. 2006 Nov;47(11):5098-105. PMID: 17065531 [PubMed - indexed for MEDLINE]

6:	Glotin AL, Calipel A, Brossas JY, Faussat AM, Treton J, Mascarelli F.
	Sustained versus transient ERK1/2 signaling underlies the anti- and proapoptotic effects of oxidative stress in human RPE cells. Invest Ophthalmol Vis Sci. 2006 Oct;47(10):4614-23. PMID: 17003459 [PubMed - indexed for MEDLINE]

7:	Tate DJ, Newsome DA.
	A novel zinc compound (zinc monocysteine) enhances the antioxidant capacity of human retinal pigment epithelial cells. Curr Eye Res. 2006 Jul-Aug;31(7-8):675-83. PMID: 16877276 [PubMed - indexed for MEDLINE]

8:	Sreekumar PG, Kannan R, de Silva AT, Burton R, Ryan SJ, Hinton DR.
	Thiol regulation of vascular endothelial growth factor-A and its receptors in human retinal pigment epithelial cells. Biochem Biophys Res Commun. 2006 Aug 11;346(4):1200-6. Epub 2006 Jun 12. PMID: 16793007 [PubMed - indexed for MEDLINE]

9:	Ha KN, Chen Y, Cai J, Sternberg P Jr.
	Increased glutathione synthesis through an ARE-Nrf2-dependent pathway by zinc in the RPE: implication for protection against oxidative stress. Invest Ophthalmol Vis Sci. 2006 Jun;47(6):2709-15. PMID: 16723490 [PubMed - indexed for MEDLINE]

10:	Zhou J, Gao X, Cai B, Sparrow JR.
	Indirect antioxidant protection against photooxidative processes initiated in retinal pigment epithelial cells by a lipofuscin pigment. Rejuvenation Res. 2006 Summer;9(2):256-63. PMID: 16706653 [PubMed - indexed for MEDLINE]

11:	Yokoyama T, Yamane K, Minamoto A, Tsukamoto H, Yamashita H, Izumi S, Hoppe G, Sears JE, Mishima HK.
	High glucose concentration induces elevated expression of anti-oxidant and proteolytic enzymes in cultured human retinal pigment epithelial cells. Exp Eye Res. 2006 Sep;83(3):602-9. Epub 2006 May 11. PMID: 16697369 [PubMed - indexed for MEDLINE]

12:	Trudel E, Beaufils S, Renault A, Breton R, Salesse C.
	Binding of RPE65 fragments to lipid monolayers and identification of its partners by glutathione S-transferase pull-down assays. Biochemistry. 2006 Mar 14;45(10):3337-47. PMID: 16519528 [PubMed - indexed for MEDLINE]

13:	Jin M, Yaung J, Kannan R, He S, Ryan SJ, Hinton DR.
	Hepatocyte growth factor protects RPE cells from apoptosis induced by glutathione depletion. Invest Ophthalmol Vis Sci. 2005 Nov;46(11):4311-9. PMID: 16249513 [PubMed - indexed for MEDLINE]

14:	Voloboueva LA, Liu J, Suh JH, Ames BN, Miller SS.
	(R)-alpha-lipoic acid protects retinal pigment epithelial cells from oxidative damage. Invest Ophthalmol Vis Sci. 2005 Nov;46(11):4302-10. PMID: 16249512 [PubMed - indexed for MEDLINE]

15:	Ogawa T, Boylan SA, Oltjen SL, Hjelmeland LM.
	Changes in the spatial expression of genes with aging in the mouse RPE/choroid. Mol Vis. 2005 Jun 1;11:380-6. PMID: 15947738 [PubMed - indexed for MEDLINE]

16:	Jarrett SG, Boulton ME.
	Antioxidant up-regulation and increased nuclear DNA protection play key roles in adaptation to oxidative stress in epithelial cells. Free Radic Biol Med. 2005 May 15;38(10):1382-91. PMID: 15855056 [PubMed - indexed for MEDLINE]

17:	Choudhary S, Xiao T, Srivastava S, Zhang W, Chan LL, Vergara LA, Van Kuijk FJ, Ansari NH.
	Toxicity and detoxification of lipid-derived aldehydes in cultured retinal pigmented epithelial cells. Toxicol Appl Pharmacol. 2005 Apr 15;204(2):122-34. PMID: 15808518 [PubMed - indexed for MEDLINE]

18:	Liang FQ, Alssadi R, Morehead P, Awasthi YC, Godley BF.
	Enhanced expression of glutathione-S-transferase A1-1 protects against oxidative stress in human retinal pigment epithelial cells. Exp Eye Res. 2005 Jan;80(1):113-9. PMID: 15652532 [PubMed - indexed for MEDLINE]

19:	Maeda A, Crabb JW, Palczewski K.
	Microsomal glutathione S-transferase 1 in the retinal pigment epithelium: protection against oxidative stress and a potential role in aging. Biochemistry. 2005 Jan 18;44(2):480-9. PMID: 15641772 [PubMed - indexed for MEDLINE]

20:	Armstrong JS, Whiteman M, Yang H, Jones DP, Sternberg P Jr.
	Cysteine starvation activates the redox-dependent mitochondrial permeability transition in retinal pigment epithelial cells. Invest Ophthalmol Vis Sci. 2004 Nov;45(11):4183-9. PMID: 15505073 [PubMed - indexed for MEDLINE]

21:	Bridges CC, Hu H, Miyauchi S, Siddaramappa UN, Ganapathy ME, Ignatowicz L, Maddox DM, Smith SB, Ganapathy V.
	Induction of cystine-glutamate transporter xc- by human immunodeficiency virus type 1 transactivator protein tat in retinal pigment epithelium. Invest Ophthalmol Vis Sci. 2004 Sep;45(9):2906-14. PMID: 15326101 [PubMed - indexed for MEDLINE]

22:	Treichel JL, Henry MM, Skumatz CM, Eells JT, Burke JM.
	Antioxidants and ocular cell type differences in cytoprotection from formic acid toxicity in vitro. Toxicol Sci. 2004 Nov;82(1):183-92. Epub 2004 Aug 19. PMID: 15319487 [PubMed - indexed for MEDLINE]

23:	Gao X, Talalay P.
	Induction of phase 2 genes by sulforaphane protects retinal pigment epithelial cells against photooxidative damage. Proc Natl Acad Sci U S A. 2004 Jul 13;101(28):10446-51. Epub 2004 Jun 30. PMID: 15229324 [PubMed - indexed for MEDLINE]

24:	Klenotic PA, Munier FL, Marmorstein LY, Anand-Apte B.
	Tissue inhibitor of metalloproteinases-3 (TIMP-3) is a binding partner of epithelial growth factor-containing fibulin-like extracellular matrix protein 1 (EFEMP1). Implications for macular degenerations. J Biol Chem. 2004 Jul 16;279(29):30469-73. Epub 2004 Apr 28. PMID: 15123717 [PubMed - indexed for MEDLINE]

25:	Hoppe G, Chai YC, Crabb JW, Sears J.
	Protein s-glutathionylation in retinal pigment epithelium converts heat shock protein 70 to an active chaperone. Exp Eye Res. 2004 Jun;78(6):1085-92. PMID: 15109915 [PubMed - indexed for MEDLINE]

26:	Yin C, Li X.
	The effects of different intraocular irrigating solutions on the apoptosis of cultured RPE cells. Graefes Arch Clin Exp Ophthalmol. 2003 Oct;241(10):834-9. Epub 2003 Jul 25. PMID: 12898278 [PubMed - indexed for MEDLINE]

27:	Jones BW, Watt CB, Frederick JM, Baehr W, Chen CK, Levine EM, Milam AH, Lavail MM, Marc RE.
	Retinal remodeling triggered by photoreceptor degenerations. J Comp Neurol. 2003 Sep 8;464(1):1-16. PMID: 12866125 [PubMed - indexed for MEDLINE]

28:	Martinez-Morales JR, Dolez V, Rodrigo I, Zaccarini R, Leconte L, Bovolenta P, Saule S.
	OTX2 activates the molecular network underlying retina pigment epithelium differentiation. J Biol Chem. 2003 Jun 13;278(24):21721-31. Epub 2003 Mar 27. PMID: 12663655 [PubMed - indexed for MEDLINE]

29:	Chai YC, Hoppe G, Sears J.
	Reversal of protein S-glutathiolation by glutaredoxin in the retinal pigment epithelium. Exp Eye Res. 2003 Feb;76(2):155-9. PMID: 12565802 [PubMed - indexed for MEDLINE]

30:	Nelson KC, Armstrong JS, Moriarty S, Cai J, Wu MW, Sternberg P Jr, Jones DP.
	Protection of retinal pigment epithelial cells from oxidative damage by oltipraz, a cancer chemopreventive agent. Invest Ophthalmol Vis Sci. 2002 Nov;43(11):3550-4. PMID: 12407167 [PubMed - indexed for MEDLINE]