AREDS2 results published in May 2013 showed that high levels of Lutein and Zeaxanthin combined with vitamins and minerals were most effective in supporting macular health. VisiVite i-Defense Green Formula contains 50% more Lutein and 134% more Zeaxanthin than AREDS2. VisiVite Premier Ocular Formula No. 2 has pharmaceutical grade omega 3s. And VisiVite i-Defense E-Free is the doctor's choice for patients who take Coumadin or other anticoagulation therapy.