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Naturally-Sourced Macular Degeneration Vitamins since 2001

High doses of certain dietary supplements provide the first effective support for the leading cause of vision loss among the elderly, peer-reviewed scientific studies have concluded.

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Evidence Based & Dr. Approved

VisiVite Eye Vitamin Formulas are based on proven research in the most respected medical publications, including the National Eye Institute's Age-Related Eye Disease Study (AREDS) Age-Related Eye Disease Study 2 (AREDS2), the Lutein Antioxidant Supplement Trial (LAST) and others. Flimsly research or mere opinions are not the method used in the creation of our supplements.

Scientific References

VisiVite Eye Vitamin Formulas are based on proven research in the most respected medical publications

Lutein + Zeaxanthin and Omega-3 Fatty Acids for Age-Related Macular Degeneration. The Age-Related Eye Disease Study 2 (AREDS2) Randomized Clinical Trial. 
JAMA. 2013;309(19):2005-2015. doi:10.1001/jama.2013.4997

A Randomized, Placebo-Controlled, Clinical Trial of High-Dose Supplementation With Vitamins C and E, Beta Carotene, and Zinc for Age-Related Macular Degeneration and Vision Loss: AREDS Report No. 8. Arch Ophthalmol .
2001 Oct;119(10):1417-36. doi: 10.1001/archopht.119.10.1417.

Double-masked, placebo-controlled, randomized trial of lutein and antioxidant supplementation in the intervention of atrophic age-related macular degeneration: the Veterans LAST study (Lutein Antioxidant Supplementation Trial).
Optometry - Journal of the American Optometric Association Volume 75, Issue 4, April 2004, Pages 216-229

Macular pigment and its contribution to visual performance and experience.
J Optom. 2010 Apr; 3(2): 74–90.

Changes in macular pigment optical density and serum concentrations of its constituent carotenoids following supplemental lutein and zeaxanthin: The LUNA study.
Experimental Eye Research Volume 84, Issue 4, April 2007, Pages 718-728

Effect of Lutein and Zeaxanthin on Macular Pigment and Visual Function in Patients with Early Age-related Macular Degeneration. Ophthalmology Volume 119, Issue 11, November 2012, Pages 2290-2297

Nutritional Manipulation of Primate Retinas, V: Effects of Lutein, Zeaxanthin, and n–3 Fatty Acids on Retinal Sensitivity to Blue-Light–Induced Damage. Investigative Ophthalmology & Visual Science June 2011, Vol.52, 3934-3942. doi:https://doi.org/10.1167/iovs.10-5898

Lutein and zeaxanthin supplementation reduces photooxidative damage and modulates the expression of inflammation-related genes in retinal pigment epithelial cells. Free Radical Biology and Medicine Volume 53, Issue 6, 15 September 2012, Pages 1298-1307

Lutein and Zeaxanthin Supplementation and Association With Visual Function in Age-Related Macular Degeneration. Investigative Ophthalmology & Visual Science January 2015, Vol.56, 252-258. doi:https://doi.org/10.1167/iovs.14-15553

Improvement of Retinal Function in Early Age-Related Macular Degeneration After Lutein and Zeaxanthin Supplementation: A Randomized, Double-Masked, Placebo-Controlled Trial. American Journal of Ophthalmology Volume 154, Issue 4, October 2012, Pages 625-634.e1

Vitamin E Serum Levels and Bleeding Risk in Patients Receiving Oral Anticoagulant Therapy: A Retrospective Cohort Study. J Am Heart Assoc . 2013 Oct 28;2(6):e000364. doi: 10.1161/JAHA.113.000364.

Drug and dietary interactions of the new and emerging oral anticoagulants. The International Journal of Clinical Practice Omenn GS, Goodman GE, et al.

Effects of a combination of beta carotene and vitamin A on lung cancer and cardiovascular disease. N Engl J Med. 1996;334:1150-1155. Virtamo J, Pietinen P, et al.

Incidence of cancer and mortality following alpha-tocopherol and beta-carotene supplementation: a postintervention follow-up. JAMA. 2003;290:476-485.

Lutein and zeaxanthin in eye and skin health. Clinics in Dermatology Volume 27, Issue 2, March–April 2009, Pages 195-201

Macular Pigment and Healthy Vision. Journal of Optometry, 2009.

SIRT1 Is Required for AMPK Activation and the Beneficial Effects of Resveratrol on Mitochondrial Function. Cell Metabolism, Volume 15, Issue 5, 2 May 2012, Pages 566-567

Essential fatty acids and the brain: possible health implications. International Journal of Developmental Neuroscience Volume 18, Issues 4–5, 1 July 2000, Pages 383-399

Zinc Fact Sheet for Health Professionals. National Institutes of Health Office of Dietary Supplements

CFH and ARMS2 Genetic Polymorphisms Predict Response to Antioxidants and Zinc in Patients With Age-Related Macular Degeneration. Ophthalmology. 2013 Nov;120(11):2317-23.

Treatment Response to Antioxidants and Zinc Based on CFH and ARMS2 Genetic Risk Allele Number in the Age-Related Eye Disease Study. Ophthalmology. 2013 Nov;120(11):2317-23.

Response to AREDS Supplements According to Genetic Factors: Survival Analysis Approach Using the Eye as the Unit of Analysis. Br J Ophthalmol . 2016 Dec;100(12):1731-1737.

CFH and ARMS2 genetic risk determines progression to neovascular age-related macular degeneration after antioxidant and zinc supplementation. Proceedings of the National Academy of Sciences of the United States of America. January 23, 2018

Correspondence Reply Re: Genetic polymorphisms of CFH and ARMS2 do not predict response to antioxidants and zinc in patients with age related macular degeneration. Ophthalmology. 2018.

Prospective Assessment of Genetic Effects on Progression to Different Stages of Age-Related Macular Degeneration Using Multistate Markov Models. Invest Ophthalmol Vis Sci. 2012 Mar; 53(3): 1548–1556.

Validation of a Prediction Algorithm for Progression to Advanced Macular Degeneration Subtypes. JAMA Ophthalmol. 2013 Apr; 131(4): 448–455.

The Value of Measurement of Macular Carotenoid Pigment Optical Densities and Distributions in Age-Related Macular Degeneration and Other Retinal Disorders. Vision Res. 2010 Mar 31;50(7):716-28. 

A Double-Blind, Placebo-Controlled Study on the Effects of Lutein and Zeaxanthin on Photostress Recovery, Glare Disability, and Chromatic Contrast. Invest Ophthalmol Vis Sci. 2014 Dec 2;55(12):8583-9. 

Macular pigment: influences on visual acuity and visibility. Prog Retin Eye Res. 2002 Mar;21(2):225-40. 

Xanthophyll accumulation in the human retina during supplementation with lutein or zeaxanthin – the LUXEA (LUtein Xanthophyll Eye Accumulation) study. Archives of Biochemistry and Biophysics. Volume 458, Issue 2, 15 February 2007, Pages 128-135 

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