The journal Ophthalmology, compared the injection of Lucentis (ranibizumab) and Avastin (bevacizumab) into mice. Lucentis and Avastin had similar efficacy at suppressing sub-retinal neovascularization (wet macular degeneration) in mice but the effect lasted longer with Avastin.
One possible reason for this is that Avastin is a larger molecule and doesn't disappear as quickly from the vitreous humor.
