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Mice aren't human, but this could be important!

The journal Ophthalmology, compared the injection of Lucentis (ranibizumab) and Avastin (bevacizumab) into mice. Lucentis and Avastin had similar efficacy at suppressing sub-retinal neovascularization (wet macular degeneration) in mice but the effect lasted longer with Avastin.

One possible reason for this is that Avastin is a larger molecule and doesn't disappear as quickly from the vitreous humor. 

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